Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions consist of:
1996, initial mesoscopic cost density waves equipment; and very first electrical measurements on only one metal nanocluster amongst nanoelectrodes
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Our get the job done was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors made from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2010, made a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-state nanopores
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental job of spatial confinement at the molecular and mobile amount. Our initiatives include things like the subsequent:
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in pink, as well as a 3D rendering of the motion of the DNA rod is shown.
The rotors harness Electricity from a nanoscale water and ion stream which is generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to developing Strength-transducing motors at nanoscale interfaces.
But carbon nanotubes have remained a analysis subject of substantial interest to many. Indeed, the outlook on using carbon nanotubes to build practical equipment, in ceesdekker parts for instance radio-frequency electronics, digital electronics and flexible electronics, continues to be shiny.
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim in the pore is highlighted in red, and a 3D rendering of your movement in the DNA rod is displayed.
2001, discovery of one-electron transistors at home temperature based on nanotubes; realization of initial logic circuits with carbon nanotube gadgets; and discovery on the molecular framework of DNA repair service enzymes with AFM
Let’s initial search back again for the time being once you chose to shift your emphasis from superconductivity and nanotubes to biology at the end of the nineties.
2004, discovery of recent physics in translocation of DNA by means of nanopores; first experimental analyze of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization of the mechanical Houses of double-stranded RNA; and very first one-molecule research of DNA translocation by a restriction-modification enzyme.